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. 2024 Jan 22;15:668. doi: 10.1038/s41467-024-44969-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Uniform manifold approximation and projection (UMAP) embedding of single-cell transcriptomes from day6-blastoids generated in AggreWell. b Expression of human EPI markers IFI16, POU5F1 and NANOG and TE markers GATA2 and NR2F2. c Expression level of blastocyst lineage markers in each cluster. d Heat map showing the expression levels of the top 50 genes that are enriched in each cluster. Expression levels: z-scores. e, f UMAP of single-cell transcriptomes of cells from day6-blastoids (f) integrated with published datasets from human early embryos (e). g Rename the clusters (defined in a on the basis of similarities to human blastocyst lineages). h RNA velocity analysis indicating the cell trajectories shown in arrows.