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. 2024 Jan 22;15:668. doi: 10.1038/s41467-024-44969-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative time-course immunofluorescence staining images of day 1–4 aggregates/blastoids in AggreWell. Yellow arrows: SOX2⁺GATA6⁺GATA3⁻ cells; White arrows: SOX2⁻GATA6⁺GATA3⁺ cells; Pink arrows: SOX2⁺GATA6⁺GATA3⁺ cells; Blue arrows: SOX2⁻GATA6⁻GATA3⁺ cells; Scale bars, 20 μm. (n > 10). b Joint UMAP analysis and re-cluster of published human embyros/ESCs data (left) and day 0, 2, 3 and 6 spontaneous blastoid scRNA-seq data (right). c Contribution of cluster 2 and 3 to day 0, 2, 3 and 6 blastoid cells. d, e Expression levels of marker genes in cells and clusters. Source data are provided as a Source Data file.