Table 2.
Brain regions where group differences in voxelwise grey matter volume (GMV) were most pronounced in patients with idiopathic generalized epilepsy (IGE) and healthy controls (TFCE, pFWE < 0.05). Regions in which group differences in GMV were associated with group differences in physical exercise in leisure (PEL) levels and Total Mood Disturbance (TMD) scores are also summarized.
| Model | Region | Cluster size |
MNI coordinates |
|||
|---|---|---|---|---|---|---|
| (mm3) | X | Y | Z | |||
| GMV differences between groups | ||||||
| IGE > Healthy | R Cerebellum (IX) | 229 | 0 | −56 | −53 | |
| IGE < Healthy | L Gyrus Rectus | 5 | −6 | 60 | 23 | |
| Interaction of GMV*PEL | ||||||
| IGE < Healthy | L Frontal Pole | 140 | −5 | 62 | −24 | |
| Interaction of GMV*TMD | ||||||
| IGE > Healthy | R Cerebellum (IX) | 180 | 2 | −56 | −51 | |
Abbreviations: GMV, grey matter volume; IGE, idiopathic generalized epilepsy; PEL, physical exercise in leisure score of the Baecke Questionnaire of Habitual Physical Activity that represents frequency, intensity, and aerobic quality of sports and high-intensity exercises; TMD, Total Mood Disturbance score for Profile of Mood States; L, left; R, right; TFCE, threshold-free cluster enhancement.