Table 3.
Association of Meta‐Analysis Global Group in Chronic Heart Failure score with mortality according to types of valvular heart disease
| Univariable analysis | Multivariable analysis a | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Total cohort (n = 10 446) | ||||
| MAGGIC score (per 1 point increase) | 1.139 (1.130–1.149) | <0.001 | 1.095 (1.084–1.107) | <0.001 |
| AS (n = 494) b | ||||
| MAGGIC score (per 1 point increase) | 1.101 (1.051–1.154) | <0.001 | 1.053 (0.992–1.117) | 0.087 |
| MAGGIC score ≥ 17 (vs. <17) | 3.193 (1.551–6.575) | 0.002 | 1.970 (0.909–4.268) | 0.086 |
| AR (n = 1372) | ||||
| MAGGIC score (per 1 point increase) | 1.119 (1.083–1.157) | <0.001 | 1.074 (1.030–1.120) | <0.001 |
| MAGGIC score ≥ 19 (vs. <19) | 4.280 (2.545–7.198) | <0.001 | 2.351 (1.312–4.212) | 0.004 |
| MS (n = 473) c | ||||
| MAGGIC score (per 1 point increase) | 1.202 (1.107–1.306) | <0.001 | 1.156 (1.025–1.303) | 0.018 |
| MAGGIC score ≥ 19 (vs. <19) | 8.742 (2.692–28.388) | <0.001 | 5.306 (1.392–20.224) | 0.015 |
| MR (n = 2590) | ||||
| MAGGIC score (per 1 point increase) | 1.132 (1.112–1.152) | <0.001 | 1.088 (1.065–1.112) | <0.001 |
| MAGGIC score ≥ 20 (vs. <20) | 4.864 (3.612–6.552) | <0.001 | 2.677 (1.939–3.695) | <0.001 |
| TR (n = 1691) | ||||
| MAGGIC score (per 1 point increase) | 1.138 (1.113–1.163) | <0.001 | 1.113 (1.086–1.141) | <0.001 |
| MAGGIC score ≥ 18 (vs. <18) | 6.086 (3.992–9.276) | <0.001 | 4.272 (2.733–6.676) | <0.001 |
| AS + AR (n = 229) b | ||||
| MAGGIC score (per 1 point increase) | 1.161 (1.081–1.246) | <0.001 | 1.217 (1.069–1.387) | 0.003 |
| MAGGIC score ≥ 19 (vs. <19) | 6.854 (1.886–24.907) | 0.003 | 9.740 (1.827–51.935) | 0.008 |
| MS + MR (n = 173) d | ||||
| MAGGIC score (per 1 point increase) | 1.193 (1.096–1.299) | <0.001 | 1.127 (0.981–1.295) | 0.092 |
| MAGGIC score ≥ 16 (vs. <16) | 6.571 (1.418–30.436) | 0.016 | 3.506 (0.629–19.549) | 0.152 |
| MVHD (n = 3424) | ||||
| MAGGIC score (per 1 point increase) | 1.135 (1.120–1.150) | <0.001 | 1.097 (1.080–1.114) | <0.001 |
| MAGGIC score ≥ 22 (vs. <22) | 5.073 (4.083–6.303) | <0.001 | 2.837 (2.238–3.596) | <0.001 |
AR, aortic regurgitation; AS, aortic stenosis; CI, confidence interval; HR, hazard ratio; MAGGIC, Meta‐Analysis Global Group in Chronic Heart Failure; MR, mitral regurgitation; MS, mitral stenosis; MVHD, multiple valvular heart disease; TR, tricuspid regurgitation.
Adjusted for hypertension, hyperlipidaemia, coronary artery disease, cardiomyopathy, atrial fibrillation or flutter, chronic kidney disease, haemoglobin, albumin, left atrial end‐diastolic dimension, left ventricular end‐diastolic dimension, pulmonary hypertension, severity of valvular heart disease, and valvular intervention.
In patients with isolated AS or mixed AS and AR, cardiomyopathy was not adjusted because no death occurred in patients with cardiomyopathy.
In patients with MS, cardiomyopathy was not adjusted because no patient had cardiomyopathy.
In patients with mixed MS and MR, hyperlipidaemia and cardiomyopathy were not adjusted because no death occurred in patients with hyperlipidaemia and no patient had cardiomyopathy.