Table 3.
Univariable and multivariable logistic regression for the association between stages of renal dysfunction and echocardiographic measures
| E/e′ > 10 | LAVI > 30 mL/m2 | LVMI > 90 g/m2 (male)LVMI > 80 g/m2 (female) | RWT > 0.48 | ACC/AHA Stage C/D | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Model 1: Crude | ||||||||||
| eGFR categories | ||||||||||
| eGFR ≥90 mL/min/1.73 m2 | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | ref. | ‐ |
| eGFR 60–89 mL/min/1.73 m2 | 1.62 (1.20, 2.18) | 0.002 | 0.97 (0.70, 1.33) | 0.84 | 1.19 (0.87, 1.62) | 0.28 | 1.85 (1.33, 2.57) | <0.001 | 1.32 (0.99, 1.77) | 0.06 |
| eGFR <60 mL/min/1.73 m2 | 2.01 (1.22, 3.31) | 0.006 | 1.11 (0.64, 1.88) | 0.70 | 2.10 (1.27, 3.46) | 0.004 | 2.43 (1.43, 4.09) | <0.001 | 2.53 (1.55, 4.16) | <0.001 |
| Model 2: Adjusted | ||||||||||
| eGFR categories | ||||||||||
| eGFR ≥90 mL/min/1.73 m2 | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ |
| eGFR 60–89 mL/min/1.73 m2 | 1.55 (1.14, 2.11) | 0.005 | 0.92 (0.67, 1.27) | 0.61 | 1.07 (0.77, 1.58) | 0.69 | 1.75 (1.25, 2.45) | 0.001 | 1.16 (0.86, 1.57) | 0.35 |
| eGFR <60 mL/min/1.73 m2 | 1.80 (1.07, 2.98) | 0.02 | 1.06 (0.61, 1.81) | 0.83 | 1.72 (1.02, 2.88) | 0.04 | 2.09 (1.21, 3.55) | 0.007 | 2.09 (1.25, 3.51) | 0.005 |
| Model 3: Adjusted | ||||||||||
| eGFR categories | ||||||||||
| eGFR ≥90 mL/min/1.73 m2 | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ | Ref. | ‐ |
| eGFR 60–89 mL/min/1.73 m2 | 1.55 (1.10, 2.08) | 0.005 | 0.92 (0.67, 1.27) | 0.62 | 1.07 (0.77, 1.47) | 0.69 | 1.75 (1.25, 2.45) | 0.001 | 1.16 (0.85, 1.58) | 0.35 |
| eGFR <60 mL/min/1.73 m2 | 1.80 (1.07, 3.02) | 0.03 | 1.03 (0.58, 1.76) | 0.93 | 1.70 (1.00, 2.86) | 0.047 | 2.15 (1.24, 3.68) | 0.005 | 2.07 (1.23, 3.49) | 0.006 |
Model 1: Crude. Model 2: Adjusted for BMI, diabetes mellitus, hypertension, hypercholesterolaemia, and history of cardiovascular disease. Model 3: Adjusted for model 2 + alcohol of >2 units/day, current smoking, and education level. Renal function was estimated using the CKD‐EPI 2021 equation for creatinine and cystatin C in combination without race.
ACC/AHA, American College of Cardiology/American Heart Association; BMI, body mass index; CI, confidence interval; eGFR, estimated glomerular filtration rate; LAVI, left atrial volume index; LVMI, left ventricular mass index; OR, odds ratio; RWT, relative wall thickness.