TABLE 3.

Measures of continuous glucose and insulin sensitivity parameters for both randomized groups.

Variable	DCR baseline	DCR 12 weeks	Change	p‐value a	E‐TRE baseline	E‐TRE 12 weeks	Change	p‐value a	p‐value b
Average sensor glucose	95.8 (9.0)	93.2 (9.2)	−2.5 (12.0)	0.430	90.5 (10.2)	92.7 (11.1)	2.1 (11.9)	0.278	0.187
Standard deviation	15.8 (3.6)	14.0 (2.7)	−1.8 (3.7)	0.022	13.6 (3.9)	13.0 (3.0)	−0.6 (3.0)	0.474	0.228
Coefficient of variation	0.16 (0.03)	0.15 (0.03)	−0.01 (0.03)	0.041	0.15 (0.03)	0.14 (0.03)	−0.01 (0.03)	0.177	0.566
Daytime average sensor glucose	97.0 (8.6)	94.4 (10.8)	−2.6 (11.9)	0.396	92.0 (10.3)	94.6 (11.5)	2.7 (11.2)	0.195	0.131
Nighttime average sensor glucose	92.8 (11.9)	90.5 (7.3)	−2.3 (13.4)	0.564	87.3 (10.9)	88.3 (10.7)	1.0 (13.8)	0.533	0.396
MAGE	35.2 (8.6)	29.8 (6.5)	−5.4 (7.3)	0.002	29.1 (9.6)	28.6 (8.3)	−0.6 (7.0)	0.801	0.030
Glucose	77.2 (16.9)	80.4 (6.8)	3.2 (19.3)	0.386	81.2 (7.0)	83.7 (5.5)	2.2 (4.3)	0.532	0.879
Insulin	7.8 (4.9)	5.9 (3.7)	−1.9 (3.2)	0.022	8.3 (4.8)	6.8 (3.3)	−1.8 (2.8)	0.057	0.817
HOMA‐IR	1.6 (1.1)	1.2 (0.7)	−0.4 (0.7)	0.025	1.7 (1.1)	1.4 (0.7)	−0.3 (0.6)	0.111	0.666
A1c	5.4 (0.3)	5.4 (0.4)	0.0 (0.3)	0.234	5.2 (0.3)	5.2 (0.4)	0.0 (0.2)	0.601	0.618

Note: Mean (standard deviation) are presented. Bold values indicates statistical significance p < 0.05.

Abbreviations: A1c, hemoglobin A1c; HOMA‐IR, homeostatic model assessment of insulin resistance; MAGE, mean amplitude of glycemic excursions; METs, metabolic equivalents.

^a p‐value calculated from weight‐adjusted mixed model tests whether baseline differs from Week 12 within each randomized group.

^b p‐value calculated from randomized group × time interaction of weight‐adjusted mixed model tests whether the changes in each outcome from baseline to week 12 differed by randomized group.