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. 2023 Nov 22;6(4):805–827. doi: 10.20517/cdr.2023.77

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© The Author(s) 2023.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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(A) Schematic illustration of the construction of sequentially responsive nanosystem (DOX@RPMSNs) and dual-responsive drug release; (B) Total ATP concentrations of MCF7/ADR cells treated with H₂O₂ and different doses of RPMSNs; (C) The expression levels of P-gp in tumor cells with different treatments; (D) Changes of tumor volume in tumor-bearing mice with different treatments (^*P < 0.05, ^**P < 0.01, ^***P < 0.001). This figure is quoted with permission from Liu et al.^[62]; (E) Schematic illustration of the construction of co-delivery nanosystem (HPMSNs) and dual-responsive drug release; (F) The expression levels of P-gp and GCN5 in tumor cells with different treatments; (G) Changes of tumor weight in tumor-bearing mice with different treatments (^*P < 0.05, ^**P < 0.01). This figure is quoted with permission from Yuan et al.^[68]. DOX: Doxorubicin; PEG-b-PLLDA: poly (ethylene glycol) amine derivative shell.