TABLE 1.
Characteristics of the Derivation Sample According to Genetic Test Results
| Total (N = 1,015) | Positive Genetic test (n = 377) | Negative Genetic test (n = 638) | P Value | |
|---|---|---|---|---|
| Demographics | ||||
| Male | 695 (68.47) | 251 (66.58) | 444 (69.59) | 0.318 |
| Age at diagnosis, y | 50.06 ± 14.49 | 48.15 ± 14.35 | 51.20 ± 14.47 | <0.001 |
| Hypertension | 340 (33.50) | 85 (22.55) | 255 (39.97) | <0.001 |
| Diabetes | 164 (16.16) | 43 (11.41) | 121 (18.97) | 0.002 |
| Smoking history | 423 (41.67) | 140 (37.14) | 283 (44.36) | 0.024 |
| Hypercholesterolemia | 291 (28.67) | 89 (23.61) | 202 (31.66) | 0.006 |
| Skeletal muscle disease | 36 (3.55) | 23 (6.10) | 13 (2.04) | 0.001 |
| FH of DCM | 480 (47.29) | 231 (61.27) | 249 (39.03) | <0.001 |
| FH of SCD first-degree relative | 124 (12.22) | 62 (16.45) | 62 (9.72) | 0.002 |
| FH of SCD non–first degree relatives | 189 (18.62) | 87 (23.08) | 102 (15.99) | 0.005 |
| FH of skeletal myopathy | 25 (2.46) | 14 (3.71) | 11 (1.72) | 0.048 |
| NYHA functional class at first evaluation | 0.225 | |||
| I | 312 (30.74) | 116 (30.77) | 196 (30.72) | |
| II | 343 (33.79) | 114 (30.24) | 229 (35.89) | |
| III | 305 (30.05) | 125 (33.16) | 180 (28.21) | |
| IV | 55 (5.42) | 22 (5.84) | 33 (5.17) | |
| Baseline ECG | ||||
| Atrial fibrillation | 117 (11.53) | 42 (11.14) | 75 (11.76) | 0.767 |
| AV block (any degree) | 112 (11.03) | 42 (11.14) | 70 (10.97) | 0.934 |
| QRS duration, mm | 117.69 ± 29.11 | 108.98 ± 26.70 | 122.84 ± 29.27 | <0.001 |
| LBBB | 333 (32.81) | 60 (15.92) | 273 (42.79) | <0.001 |
| T-wave inversion | 368 (36.26) | 133 (35.28) | 235 (36.83) | 0.618 |
| Low QRS voltage limb leads | 131 (12.91) | 88 (23.34) | 43 (6.74) | <0.001 |
| Low QRS voltage precordial leads | 45 (4.43) | 29 (7.69) | 16 (2.51) | <0.001 |
| Baseline echocardiogram | ||||
| LVEF, % | 32.06 ± 10.45 | 32.22 ± 10.42 | 31.96 ± 10.48 | 0.741 |
| LVEF ≤35% | 639 (62.96) | 234 (62.07) | 405 (63.48) | 0.653 |
| iLVEDD, mm/m2 | 32.66 (4.97) | 32.95 (4.87) | 32.49 (5.03) | 0.179 |
| DCM phenotype | 536 (52.81) | 193 (51.19) | 343 (53.76) | 0.428 |
| iLVSD phenotype | 479 (47.19) | 184 (48.81) | 295 (46.24) | |
| MR moderate/severe | 339 (34.66) | 134 (37.02) | 205 (33.28) | 0.236 |
| RVSD (any degree) | 211 (23.16) | 90 (27.27) | 121 (20.83) | 0.027 |
Values are n (%) or mean ± SD.
AV = atrioventricular; DCM = dilated cardiomyopathy; FH = family history; iLVEDD = indexed left ventricular end-diastolic diameter; iLVSD = isolated left ventricular systolic dysfunction; LBBB = left bundle branch block; LVEF = left ventricular ejection fraction; MR = mitral regurgitation; NYHA = New York Heart Association; RVSD = right ventricular systolic dysfunction; SCD = sudden cardiac death.