Fig. 3.

[¹⁸F]PI-2620 tau-PET binding in predefined target regions. A Group level binding intensity of [¹⁸F]PI-2620 tau-PET (cerebellum scaled standardized uptake value ratio, SUV_R) for female and male AD patients and mixed sex cognitively normal individuals (CN), presented as axial overlays on a standard magnetic resonance imaging template. B Correlation of tau-PET z-scores for Braak-stage regions I–VI with the Aβ-plaque-independent microglial response (intercept) for females and males with AD. Anatomic regions are shown on an axial MRI atlas. AD female n = 14, AD male n = 10, CN mixed sex n = 5