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ADAR1-selective inhibition. H16 8-azaN duplex does not inhibit 5-HT2C (left) nor NEIL1 (right) editing by ADAR2. In vitro deaminations were performed at the following conditions: 0 – 3 μM H16 8-azaN or A/G control, 100 nM ADAR2, 5 nM substrate, 10 min (for 5-HT2C) or 30 min (for NEIL1), at 30 °C. Error bars represent standard deviation from n ≥ 3 technical replicates.
