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8-azaN as a free nucleoside (A) and an 8-azaN-modified ssRNA (B) do not inhibit ADAR1. In vitro deaminations were performed at the following conditions: 0 – 1 mM 8-azaN or 0 – 3 μM 8-azaN ssRNA, 100 nM ADAR1 p110, 5 nM 5-HT2C, 15 min, at 30 °C. Error bars represent standard deviation from n ≥ 3 technical replicates. A two-tailed Welch’s t-test was conducted between indicated groups, ns = not significant.
