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(A) 8-azaN-modified duplexes with overhangs tested for ADAR1 inhibition. Bases omitted from the original H16 8-azaN duplex sequence are in grey. (B) Data from in vitro deaminations performed at the following conditions: 0 – 3 μM 8-azaN duplex, 100 nM ADAR1 p110, 5 nM 5-HT2C, 15 min, at 30 °C. Error bars represent standard deviation from n ≥ 3 technical replicates.
