Table.

Randomized Placebo-Controlled Trials of IL-1 Inhibitors for Knee Osteoarthritis

Study, Year (Reference)	IL-1 Treatment	Patients, n	Outcome	Duration, wk	Results
Chevalier et al, 2009 (5)	Anakinra (IL-1RA)*	170	Pain	4	Null
Fleischmann et al, 2019 (6)	Antibody to IL-1α/β	350	Pain/synovitis	50	Null for both outcomes
Cohen et al, 2011 (7)	mAb to IL-1R1	160	Pain	12	Null
NCT01160822 (8)	Canakinumab (mAb to IL-1β)*	136	Pain	4	Null

IL-1 = interleukin-1; IL-1R1 = IL-1 receptor, type 1; IL-1RA = IL-1 receptor antagonist; mAb = monoclonal antibody.

^*Intra-articular administration of treatment and placebo.