TABLE 1.

Splenic immune response parameters of iNOS-deficient and control mice^a

Mouse type	CD3+ cells (% of total)b	IFN-γ production (pg/ml)c	Mac-1+ cells (% of total)d	MHC class II+ cells (% of total)e
iNOS−/−	34.67 (1.2)	888.33 (55.8)	5.33 (0.3)	53.75 (1.8)
iNOS+/+	38.0 (0.9)	885.0 (48.3)	5.33 (0.3)	51.50 (2.1)

^aTotal splenic cells from either naive iNOS^−/− or iNOS^+/+ mice were stained with fluorescent-labeled monoclonal antibodies against the leukocyte antigen indicated. Nylon wool-purified T cells (97.6% CD3⁺) were stimulated with 5 μg of ConA per ml for 3 days, and the supernatants were assayed for IFN-γ as described in Materials and Methods. Results represent data from at least three independent experiments and are expressed as means with standard errors of the means shown in parentheses. 

^bResults are significantly different at P = 0.059. 

^cResults are significantly different at P = 0.965. 

^dResults are significantly different at P = 1.0. 

^eResults are significantly different at P = 0.664.