Table 3.
Results of the mixed effects Bayesian INLA Cox proportional hazard regression model in the female breast cancer cohort, mutually adjusted and adjusted for baseline age class, year, month, patient ID, municipality of residence, and tumor morphology.
| Mixed effects INLA Cox proportional hazard regression |
Female breast cancer cohort | |
|---|---|---|
| All-cause death | ||
| N = 2,837; person-years = 10,445; n = 447 | ||
| Fixed effects | HR | 95% CrI |
| Residence in SIN | ||
| Extra-SIN | 1.00 | (ref) |
| SIN | 1.22 | 1.01–1.48 |
| Pathological/clinical staging | ||
| TNM I | 1.00 | (ref) |
| TNM II | 1.26 | 0.88–1.79 |
| TNM III | 2.77 | 1.93–3.97 |
| TNM IV | 17.05 | 11.94–24.34 |
| NA | 4.13 | 2.87–5.95 |
| Histological grading | ||
| Grade 1 | 1.00 | (ref) |
| Grade 2 | 1.93 | 0.94–3.96 |
| Grade 3 | 2.50 | 1.20–5.23 |
| NA | 2.18 | 1.02–4.66 |
| Proliferation index | ||
| Ki-67 ≤ 20% | 1.00 | (ref) |
| Ki-67 21–50% | 1.42 | 1.10–1.83 |
| Ki-67 > 50% | 1.81 | 1.29–2.55 |
| NA | 1.09 | 0.41–2.89 |
| Hormonal receptors status | ||
| ER- and PR- | 1.00 | (ref) |
| ER+ and/or PR+ | 0.61 | 0.45–0.81 |
| NA | 0.88 | 0.33–2.30 |
| Epidermal receptor status | ||
| HER2/neu- | 1.00 | (ref) |
| HER2/neu+ | 0.59 | 0.44–0.79 |
| NA | 1.40 | 0.87–2.23 |
| Topography | ||
| C50.0–1 | 1.00 | (ref) |
| C50.2–5 | 0.88 | 0.65–1.18 |
| C50.6–8 | 0.81 | 0.56–1.17 |
| NA | 0.95 | 0.67–1.34 |
| Laterality | ||
| Right | 1.00 | (ref) |
| Left | 1.03 | 0.84–1.26 |
| Bilateral | 1.65 | 1.01–2.68 |
| NA | 1.28 | 0.80–2.03 |
Province of Taranto, 2015–2020, follow-up to 31/12/2021. Time: days of follow-up. Outcome (incidence): all-cause death. N: incident cases and non-cases. n: incident cases.