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. Author manuscript; available in PMC: 2024 Jan 23.
Published in final edited form as: Nat Rev Endocrinol. 2022 Oct 26;19(3):164–176. doi: 10.1038/s41574-022-00757-5

Fig. 6 ∣. Changes in glucose regulation after bariatric surgery that hwave been linked to post-bariatric hypoglycaemia.

Fig. 6 ∣

After bariatric surgery (Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG)), nutrients are delivered rapidly to the foregut after a meal, which leads to an early and increased peak in blood levels of glucose and increased postprandial levels of glucagon-like peptide 1 (GLP1). Post-bariatric hypoglycaemia is thought to be caused by insulin-dependent mechanisms (increased insulin levels) or insulin-independent mechanisms (decreased counterregulatory hormones and changes in glucose production and uptake). FGF19, fibroblast growth factor 19; FXR, farnesoid X receptor.