Skip to main content
. Author manuscript; available in PMC: 2024 Jan 23.
Published in final edited form as: Drug Metab Rev. 2020 Jul 9;52(3):333–365. doi: 10.1080/03602532.2020.1772281

Figure 1.

Figure 1.

Glutathione conversion of AZD1979 in the active site of GST, proceeding via protonation of the cyclic aminyl nitrogen of the strained spiro-azetidinyl moiety and subsequent attack by deprotonated GSH (GS−).