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Proposed metabolic pathways and novel metabolites of pazopanib. (A) Formation of aldehyde metabolites M14 and M15. (B) Structures of N-oxide metabolite, M3, and (C) cysteine adduct, M18. Pazopanib metabolite structures were elucidated by high-resolution mass spectrometry and tandem MS fragmentation patterns (Wang et al., 2019).
