Figure 12.

Interrogation of whether mitochondrial dysfunction induces liver injury in mice models of idiosyncratic liver injury (Cho et al., 2019). C57BL/6 mice treated with rotenone and isoniazid led to minimal liver injury, yet the combined exposure to both drugs induced lethality. Rotenone and isoniazid inhibit complex I and II of the mitochondrial electron transport chain, respectively, and are thought to induce mitochondrial dysfunction (not assayed in this study; red question marks). Moreover, the study did not consider off target effects of the molecules as possible contributors to observed lethality.