Table 1.

Articles covered in this review.

	Title	Authors	Source
Metabolites and drug metabolizing enzymes
1	Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation	Li XQ, Grönberg G, Bangur EH, Hayes MA, Catagnoli Jr. N, Weidolf L	Drug Metabolism Disposition 47:1247–1256, 2019
2	Biotransformation of Myricetin: A Novel Metabolic Pathway to Produce Aminated Products in Mice	Zhang S, Wang R, Zhao Y, Tareq FS, Sang FS	Molecular Nutrition and Food Research 63(14):1900203, 2019
3	The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics	Di L	Current Drug Metabolism 20:91–102, 2019
4	Biocatalytic Reversal of Advanced Glycation End Product Modification	Kim NY, Goddard TN, Sohn S, Spiegel DA, Crawford JM	ChemBioChem 20:2402–2410, 2019
5	Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis	He F, Mori T, Morita I, Nakamura H, Alblova M, Hoshino S, Awakawa T, Abe I	Nature Chemical Biology 15:1206–1213, 2019
6	Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans	Podoll T, Pearson PG, Evarts J, Ingallinera T, Bibikova E, Sun H, Gohdes M, Cardinal K, Sanghvi M, Slatter JG	Drug Metabolism Disposition 47:145–154, 2019
7	Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates	Zhang D, Fourie-O’Donohue A, Dragovich PS, Pillow TH, Sadowsky JD, Kozak KR, Cass RT, Liu L, Deng Y, Liu Y, Hop CECA, Khojasteh SC	Drug Metabolism Disposition 47(10):1156–1163, 2019
Bioactivation and Safety
8	Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase in Vitro	Guo Y, Jia Y, Han L, Zhao Y, Li W, Zhang Z, Peng Y, Zheng J	Chemical Research in Toxicology 32:2459–2465, 2019
9	Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo	Tailor A, Waddington J, Hamlett J, Maggs J, Kafu L, Farrell J, Dear G, Whitaker P, Naisbitt D, Park K, Meng X	Chemical Research in Toxicology 32(10):2095–2106, 2019
10	Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model	Ji C, Guha M, Zhu X, Whritenour J, Hemkens M, Tse S, Walker G, Evans E, Khan N, Finkelstein M, Callegari E, Obach R	Chemical Research in Toxicology 32:2095–2106, 2019
11	Structure-activity Relationships of CYP4B1 Bioactivation of 4-ipomeanol Congeners: Direct Correlation Between Cytotoxicity and Trapped Reactive Intermediates.	Kowalski JP, McDonald MG, Whittington D, Guttman M, Scian M, Girhard M, Hanenberg H, Wiek C, Rettie AE	Chemical Research in Toxicology 32:2488–2498, 2019
12	A Metabolomic Perspective of Pazopanib-induced Acute Hepatotoxicity in Mice.	Wang YK, Yang XN, Liang WQ, Xiao Y, Zhao Q, Xiao, Gonzalez FJ, Li F	Xenobiotica 49(6):655–670, 2019
13	Rotenone Increases Isoniazid Toxicity but Does Not Cause Significant Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain Is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury	Cho T, Wang X, Uetrecht J	Chemical Research in Toxicology 32:1423–1431, 2019
14	Mechanism of Idiosyncratic Drug-Induced Liver Injury Quantitative Evaluation of Reactivity and Toxicity of Acyl Glucuronides by [35S]-Cysteine Trapping	Harada H, Toyoda Y, Abe Y, Endo T, Takeda H	Chemical Research in Toxicology 32:1955–1964, 2019