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. 2023 Nov 1;28(1):e18020. doi: 10.1111/jcmm.18020

FIGURE 4.

FIGURE 4

KIRREL overexpression promotes proliferation of GC cells. (A) The lentivirus transfection rate of SNU‐5 cells in each group was more than 80%; scale bar: 100 μm; Expression of KIRREL gene encoded protein (B, C) and KIRREL mRNA (D) in SNU‐5 cells transfected with lentivirus. (E) The results of CCK‐8 showed that the cell proliferation ability of SNU‐5 cell line was significantly reduced after KIRREL gene silencing compared with the control group. (F) The lentivirus transfection rate of AGS cells in each group was more than 80%; scale bar: 100 μm; Expression of KIRREL gene encoded protein (G, H) and KIRREL mRNA (I) in AGS cells transfected with lentivirus. (J) The CCK‐8 results showed that the proliferation of AGS cells was significantly enhanced after KIRREL gene overexpression compared with the control group (Control: blank control group; SH‐NC, NC: negative control group; SH‐1, SH‐2, SH‐3: Three types of knockdown groups; KIRREL: overexpression group; repetition = 3; *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significant difference).