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. 2024 Jan 23;15:680. doi: 10.1038/s41467-023-44178-y

Fig. 5. DEL-1 expression correlates with enhanced circulating neutrophils and lower mortality in septic human subjects.

Fig. 5

a Fold increase in neutrophil numbers within 24 hours in human neonates with sepsis with either low serum DEL-1 concentration (<700 pg/ml) or high serum DEL-1 concentration (>700 pg/ml) (in the group with low serum DEL-1, at day 0, the neutrophil numbers were set as 1) (n = 12 neonates per group). 28-day mortality rate (%) in (b) septic neonates (n = 12 neonates per group) and (c) adults (n = 25 adults in the group wtih low serum DEL-1 concentration and n = 15 adults in the group with high serum DEL-1 concentration) with either low DEL-1 or high DEL-1 concentration in the serum (the threshold for high/low DEL-1 concentration was determined to 125 pg/ml for adult patients and 700 pg/ml for neonates). Mean ± SD (a) and frequency (%) (b, c) are depicted. Statistical analysis with one-way ANOVA with Bonferroni multiple comparison post-test (a) and Chi-squared test (for 28-day mortality categorical data b, c). Source data are provided as a Source Data file.