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. 2024 Jan 23;15:680. doi: 10.1038/s41467-023-44178-y

Fig. 7. DEL-1 supports multipotent progenitors upon sepsis in neonates.

Fig. 7

a Long-term hematopoietic stem cells (LT-HSCs, CD48−CD150+LSK) [n = 4 animals per group in control wild type (WT) and Del1−/− groups, and n = 5 animals per group in septic WT and Del1−/− groups] b short-term HSCs (ST-HSCs, CD48−CD150−LSK) (n = 4 animals per group in control WT and Del1−/− groups, and n = 5 animals per group in septic WT and Del1−/− groups) c multipotent progenitors (MPPs, CD48+CD150−LSK) and (n = 4 animals per group in control WT and Del1−/− groups, and n = 5 animals per group in septic WT and Del1−/− groups) d myeloid-biased MPPs (MPP3s, Flt3−CD48+CD150−LSK) (n = 4 animals per group in control WT and Del1−/− control groups and n = 5 animals per group in septic WT and Del1−/− groups) and e representative flow cytometry plots of MPP and MPP3 cells in the bone marrow of WT and Del1−/− C57BL/6 neonate mice at steady state (gray background) and at 12 hours of cecal slurryinduced polymicrobial sepsis. Mean ± SD is depicted (a–d). Statistical analysis by unpaired two-sided t test between WT and Del1−/− control groups (gray background, a–d) and between WT and Del1−/− septic groups (a–d). Source data are provided as a Source Data file. LSK (Lin−Sca-1+cKit+), Ctl control, h hours.