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. 2024 Jan 23;15:680. doi: 10.1038/s41467-023-44178-y

Fig. 8. DEL-1 prevents the decline of granulocyte progenitors upon sepsis in neonates.

Fig. 8

a Representative flow cytometry plots of granulocyte-macrophage progenitors (GMPs) (Lin−c-Kit+ Sca-1−CD16/32+CD34+) in wild-type (WT) and Del1−/− C57BL/6 neonate pups at 12 hours of cecal slurry (CS)-induced sepsis b percentage of GMPs in WT and Del1−/− C57BL/6 neonate pups at basal state and following 12 and 24 hours of CS-induced sepsis (n = 9 animals in control WT, n = 11 animals in Del1−/− control, n = 7 animals in WT 12 h sepsis, n = 6 animals in Del1−/− 12 h sepsis, n = 6 animals in WT 24 h sepsis and n = 8 animals in Del1−/− 12 h sepsis groups). c percentage of GMPs in WT neonate mice and Del1−/− C57BL/6 neonate mice treated with i.v. DEL-1-Fc or IgG-Fc 15 min prior to injection of CS and following 12 hours of CS-induced sepsis (n = 5 animals per group). Mean ± SD is depicted (b, c). Statistical analysis by one-way ANOVA with Bonferroni’s multiple comparison post-test (c) and unpaired two-sided t test between WT and Del1−/− control groups of the same time point (b, as indicated). Source data are provided as a Source Data file. Ctl control, h hours.