Table 3.

Characteristics of patients with autoimmune hepatitis.

Baseline characteristics	Patients, n = 4 (%)
Treatment regime before ICI treatment#
Corticosteroids (5 mg per day)	1 (25)
Mycophenolate mofetil (2 g per day)	1 (25)
Azathioprine*	2 (50)
None	1 (25)
IgG levels before ICI treatment
Median (Range) in g/l	10.1 (5.3 - 30.8)
Not available	1 (25)
ALT levels before ICI treatment
Median (Range) in IU/l	26.3 (18.0 - 33.0)
Time on current immunosuppressive treatment for AIH before ICI therapy
Mean (Months) ± SD	30.6 ± 6.0
Treatment adjustment during ICI therapy due to ILICI
Start of corticosteroids (15 mg per day)	1 (25)
Increase of corticosteroids (5 mg per day)	1 (25)
No treatment adjustment	1 (25)
Treatment adjustment during ICI therapy due to AILD#
Stop of immunosuppression	1 (25)
No treatment adjustment	1 (25)
Highest ALT levels during ICI treatment
Mean (Range) in IU/l	54.75 (40 – 80)
Weeks until normalization of liver enzymes after hepatic irAE
Mean (Range)	10 (2 – 18)

^#Multiple treatments possible; *Azathioprine: 100 mg and 50 mg per day respectively.