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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Br J Pharmacol. 2023 Aug 19;180(24):3130–3145. doi: 10.1111/bph.16197

Figure 5. MJN110 does not reduce cue-induced fear expression but reduces fear in the absence of cues selectively in male msP rats.

Figure 5.

Rats were tested for conditioned fear expression 3 hours after a single MJN110 administration (5 mg kg−1, i.p.). Female conditioned fear acquisition day 1. A) % freezing during 5 min before CS+US presentation. B) % freezing during CS+US pairing presentations. Male conditioned fear acquisition day 1. C) % freezing during 5 min before CS+US presentation. D) % freezing during CS+US pairing presentations. Female conditioned fear acquisition day 2. E) % freezing during 5 min before CS+US presentation. F) % freezing during CS+US pairing presentations. Male conditioned fear acquisition day 2. G) % freezing during 5 min before CS+US presentation. H) % freezing during CS+US pairing presentations. Female conditioned fear expression. I) % freezing during 5 min before CS presentation. J) % freezing during CS presentations. The 18 CS were analyzed as 3 bins of 6 sequential CS. Male conditioned fear expression. K) % freezing during 5 min before CS presentation. L) % freezing during CS presentations. The 18 CS were analyzed as 3 bins of 6 sequential CS. Results are expressed as mean ± SEM. Female Wistar vehicle, n = 10; female Wistar MJN110, n = 10; female msP vehicle, n = 10; female msP MJN110, n = 10; male Wistar vehicle, n = 10; male Wistar MJN110, n = 10; male msP vehicle, n = 10; male msP MJN110, n = 10. A, C, E, G ### p < 0.001 unpaired t-test. B, D, F, H # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001, Wistar vs msP rats, RM two-way ANOVA followed by Bonferroni’s multiple comparisons test. I, K * p < 0.05, msP vehicle vs msP MJN110, two-way ANOVA followed by Tukey’s multiple comparisons test. J, L RM two-way ANOVA followed by Bonferroni’s multiple comparisons test, # p < 0.05, ## p < 0.01, #### p < 0.0001, Wistar vs msP rats; @ p < 0.05, @@@ p < 0.001, @@@@ p < 0.0001 msP CS 1–6 vs CS 7–12 or CS 13–18.