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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Br J Pharmacol. 2023 Aug 19;180(24):3130–3145. doi: 10.1111/bph.16197

Table 1.

Effect of MJN110 on the individual aggressive, defensive, and general active behaviors.

Female Male
Wistar msP Wistar msP
Vehicle MJN110 Vehicle MJN110 Vehicle MJN110 Vehicle MJN110
Aggressive
Bite 0.0±0.0 0.0±0.0 0.1±0.1 0.0±0.0 1.5±0.8 0.0±0.0 0.1±0.1 1.3±0.8
Box 1.0±0.5 0.9±0.6 1.2±0.7 1.5±0.6 4.6±2.3 1.9±1.3 0.4±0.3 2.1±0.9
Side 0.0±0.0 0.9±0.6 3.9±1.8 0.3±0.2 0.1±0.1 2.6±1.7 0.6±0.4 3.3±1.1
Follow 9.4±1.2 10.6±1.7 11.3±1.1 5.8±1.2 13.1±3.2 7.4±2.0 10.1±1.7 10.0±1.9
Mount 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 2.0±1.0 1.0±0.7 0.1±0.1 0.1±0.1
Rattle 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0
Defensive
Avoid 10.8±1.9 15.6±2.0 10.8±1.7 14.9±1.9 6.9±1.6 11.4±2.2 10.0±1.3 24.9±2.1
Dig 3.4±1.4 0.6±0.5 0.0±0.0 0.4±0.4 0.3±0.3 0.3±3.2 0.1±0.1 2.1±1.1
Freeze 0.6±0.6 4.8±1.3 6.2±2.5 9.5±2.8 6.8±3.8 8.6±3.2 4.6±1.9 5.4±2.1
Jump 0.1±0.1 0.2±0.3 0.0±0.0 0.4±0.2 0.0±0.0 0.1±0.1 0.0±0.0 0.4±0.2
Startle 0.5±0.3 0.2±0.2 0.5±0.3 1.1±0.4 0.4±0.2 0.5±0.3 2.3±1.2 6.0±1.2
Vocalization 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0 0.0±0.0
Active
Groom 3.4±1.6 0.1±0.1 2.1±0.8 2.0±0.7 0.4±0.3 0.0±0.0 1.9±0.5 0.7±0.4
Rear 12.4±1.7 13.0±1.2 10.8±2.2 16.1±1.4 11.8±1.9 10.3±1.3 12.1±1.5 8.4±2.1
Explore 7.5±1.7 3.4±1.4 2.2±0.9 1.5±0.8 1.5±0.7 1.3±1.3 1.6±0.5 1.4±0.7

Data are presented as number of events’ mean ± SEM.