Skip to main content
. 2024 Jan 10;14:1330029. doi: 10.3389/fmicb.2023.1330029

Table 1.

Effect of plant extracts on Helicobacter pylori.

Treatment method Compound Source MIC/MBC/IZD Ref.
Antibiotic therapy Metronidazole —— MIC: 2.24 μg/mL Hassan et al. (2016)
Amoxicillin —— MIC: 13.50 μg/mL Hassan et al. (2016)
IZD: 15.0 mm Zhang and Yue (2017)
Tetracycline —— MIC: 0.25 μg/mL Feng et al. (2023)
Clarithromycin —— MIC: 1.95 μg/mL Ayoub et al. (2022)
IZD: 12.98 mm Fagni Njoya et al. (2022)
Phytotherapy The methanol extracts Alstonia boonei IZD: 7–36 mm Fagni Njoya et al. (2022)
Diterpenoids Icacina trichantha (Icacinaceae) MIC: 8–64 μg/mL Xu et al. (2021)
Naringenin (from essential oil) Cannabis sativa L. MIC50: 16 μg/mL Zengin et al. (2018)
MIC90: 32 μg/mL
Eugenol essential oil Syzygium aromaticum MIC: 23.0–51.0 μg/mL Elbestawy et al. (2023)
IZD: 10 ± 06–22 ± 04 mm
Essential oil Thymus serpyllum MIC: 2.0–4.0 μL/mL Knezevic et al. (2018)
Thyme Thymus vulgaris L. MIC: 15.6 mg/L Korona-Glowniak et al. (2020)
MBC: 15.6 mg/L
Ylang-Ylang Thomson, Annonaceae MIC: 15.6 mg/L Korona-Glowniak et al. (2020)
MBC: 62.5 mg/L
Oregano Origanum vulgare L. MIC: 31.3 mg/L Korona-Glowniak et al. (2020)
MBC: 31.3 mg/L
Lavender oil Lavandula angustifolia Mill. MIC: 62.5 mg/L Korona-Glowniak et al. (2020)
MBC: 125 mg/L
Carvacrol Satureja hortensis MIC: 0.13 mg/mL Lesjak et al. (2016)
Alkaloids Rhizoma Coptidis MIC: 25–50 μg/mL Li et al. (2018)
MBC: 37.5–125 μg/mL
Essential Oil Mentha Cultivars MIC of H. pylori strain ATCC 43504: 15.6–31.3 mg/L Piasecki et al. (2023)
Ethyl acetate Persea americana Mill. MIC: 128 μg/mL Athaydes et al. (2022)
MBC: 256 μg/mL
Essential oil Pimenta racemosa MIC: 50 μg/mL Ayoub et al. (2022)
Thymol Lamiaceae and Apiaceae families MIC: 4–128 μg/mL Sisto et al. (2021)
MBC:4–128 μg/mL
The methanol extracts Aframomum pruinosum Gagnepain seeds MIC: 128–512 μg/mL Kouitcheu Mabeku et al. (2017b)
The hydroethanolic extracts Arrabidaea chica leaves MIC: 12.5 mg/mL Mafioleti et al. (2013)
The ether extracts1-8 Desmostachya bipinnata (L.) MIC: 12.5–50 mg/mL Ibrahim et al. (2018)
The methanol extracts Bryophyllum pinnatum (Lam.) Kurz leaves MIC: 32 μg/mL Kouitcheu Mabeku et al. (2017a)
MBC: 256 μg/mL
The methanol extracts Fenugreek MIC: 100 μg/mL Hasna et al. (2023)
MBC: 150 μg/mL
The methanol extracts Cumin MIC: 150 μg/mL Hasna et al. (2023)
MBC: 250 μg/mL
The ethanol extracts White rose petal MIC: 0.10 mg/mL Park et al. (2016)
The butanol extracts White rose petal MIC: 0.01 mg/mL Park et al. (2016)
Essential oil Thymus vulgaris MIC: 62.5 μg/mL Chama et al. (2020)
Essential oil Cinnamomum glanduliferum (Wall) Meissn bark MIC: 0.49 μg/mL Taha and Eldahshan (2017)
The acetone extracts Heterotheca inuloides (Mexican arnica) MIC: 31.25 μg/mL Egas et al. (2018)
The bark extracts Spathodea campanulata MIC: 0.125 mg/mL Ngnameko et al. (2019)
The leaves extracts Nicotina tabacum MIC: 1.0 mg/mL Ngnameko et al. (2019)
The leaves extracts Allanblackia florinbunda MIC: 2.0 mg/mL Ngnameko et al. (2019)
Irigenin Iris confusa MIC: 3.90 μg/mL Abdel-Baki et al. (2022)
1-hydroxybenzoisochromanquinone Aerial parts of Mitracarpus hirtus MIC: 0.0625 μg/mL Xu et al. (2022)
Benzo[g]isoquinoline-5,10-dione Aerial parts of Mitracarpus hirtus MIC: 0.125 μg/mL Xu et al. (2022)
Nimbolide The neem tree (Azadirachta indica A. Juss) MIC of H. pylori strain G27: 2.5 μg/mL Wylie et al. (2022)
MBC of H. pylori strain G27: 5 μg/mL
Nimbolide The neem tree (Azadirachta indica A. Juss) MIC of H. pylori strain 26,695: 1.25 μg/mL Wylie et al. (2022)
MBC of H. pylori strain 26,695: 10 μg/mL
Nimbolide The neem tree (Azadirachta indica A. Juss) MIC of H. pylori strain HPAG1: 2.5 μg/mL Wylie et al. (2022)
MBC of H. pylori strain HPAG1: 10 μg/mL
The aqueous extracts Alstonia boonei IZD: 7–35 mm Fagni Njoya et al. (2022)
The methanol extracts Alstonia boonei IZD: 7–36 mm Fagni Njoya et al. (2022)
The volatile oil of CAL Chenopodium ambrosioides L. (CAL) MIC: 16 mg/L Ye et al. (2015)
The dichloromethane extracts Parthenium hysterophorus MIC: 15.6 mg/mL Espinosa-Rivero et al. (2015)
The aqueous extracts Hibiscus sabdariffa L. (Malvaceae; AEHS) MIC: 9.18–16.68 mg/mL Hassan et al. (2016)
The hydroethanolic extracts Cochlospermum regium (Bixaceae) MIC: 100 μg/mL Arunachalam et al. (2019)
The methanol extracts Bryophyllum pinnatum MIC: 32 μg/mL Kouitcheu Mabeku et al. (2017a)
MBC: 256 μg/mL
Essential oil Casearia sylvestris leaves MIC: 125 μg/mL Spósito et al. (2019)
The leaf extracts Centella asiatica leaves MIC: 0.125–8 mg/mL Zheng et al. (2016)
Essential Oil Campomanesia lineatifolia leaves MIC: 6 μL/mL Neves et al. (2022)
Neem oil Azadirachta indica seeds MIC of H. pylori strain F40/499: 64 μg/mL Cesa et al. (2019)
MBC of H. pylori strain F40/499: 64 μg/mL
Trichanthol Icacina trichantha (Icacinaceae) MIC: 8–64 μg/mL Dinat et al. (2023)
The leaf oil Pachira aquatica Aubl. MIC: 20 μg/mL Gamal El-Din et al. (2018)
Essential oil Piper longum MIC: 1.95 μg/mL Al-Sayed et al. (2021)
Essential oil White pepper MIC: 3.90 μg/mL Al-Sayed et al. (2021)
Essential oil Piper nigrum MIC: 7.81 μg/mL Al-Sayed et al. (2021)
The methanol extracts Bergenia ciliata MIC: 12.50 mg/mL Ali et al. (2020)
The ethyl acetate fraction Hibiscus rosa-sinensis red flower MIC: 0.2–0.25 mg/mL Ngan et al. (2021)
MBC: 1.25–1.5 mg/mL
The aqueous extract (AE) and 75% hydroalcoholic extracts (HE) The dried flower bud of Syzygium aromaticum MICAE and HE: 160–320 μg/mL Peng et al. (2022)
Naringenin Hibiscus rosa sinensis L. flower MBC: 1000 mg/L Tran Trung et al. (2020)

MIC, Minimum inhibitory concentration; MBC, Minimum bactericidal concentration; IZD, Inhibition zone diameter.