Table 2.
The type of probiotic that inhibits Helicobacter pylori.
| Probiotics | Source | Function | Effect | Ref. |
|---|---|---|---|---|
| Lactobacillus reuteri DSM 17648 | Probiotic capsule | Improving the eradication rate of H. pylori and reducing symptoms such as abdominal discomfort | The probiotic group had an eradication rate of 91.1% compared to the placebo group (68.9%) | Ismail et al. (2023) |
| Lactobacillus johnsonii No. 1088 | Gastric juice | Have the strongest acid resistance; inhibit the growth of H. pylori | When co-cultured with L. johnsonii No.1088, the level of H. pylori decreased to about 1/3,000 | Aiba et al. (2015) |
| Lactobacillus salivarius LN12 | —— | Destroy the biofilm of H. pylori and inhibit the growth of H. pylori | After probiotic treatment, the morphology of the H. pylori biofilm changes from a helical arrangement to a loose, broken and cracked one | Jin and Yang (2021) |
| Lactobacillus acidophilus NCFM | Compound Lactobacillus Tablets | Reduce the adhesion of H. pylori to AGS cells and reduce the occurrence of stomach inflammation | The mRNA and protein expression levels of pro-inflammatory cytokines (IL-8 and TNF-α, etc.) in probiotic group were significantly inhibited. The urease activity (urea A and urea B) in the treatment group decreased significantly | Shen et al. (2023) |
| Lactobacillus plantarum ZJ316 | Fresh fecal samples from children | Reduce the secretion of interleukin-6 (IL-6), promote the release of IL-10, and repair mucosal damage | L. plantarum ZJ316 could inhibit the urease activity of H. pylori with an inhibitory rate of 67.47% ± 2.36% | Zhou et al. (2021) |
| Lacticaseibacillus casei T1 | —— | Reduce the oxidative stress caused by H. pylori, improve the inflammatory reaction and reduce the damage of gastric mucosa. | The expression levels of pro-inflammatory cytokines, such as IL-6 and TNF-α, were significantly decreased in the probiotic group | Yu et al. (2023) |
| Lactiplantibacillus pentosus SLC13 | Mustard pickles | Modulat inflammatory response, reduce urease activity and attachment on the cells | The cell-free supernatant of L. pentosus SLC13 inhibited the growth of 78% of H. pylori | Thuy et al. (2022) |
| Lactobacillus rhamnosus JB3 | Dairy product | Interfere with H. pylori pathogenesis | L. rhamnosus JB3 inhibited the expression of VacA gene in H. pylori cells with multiplicity of infections (MOI) of 25 and 50 | Do et al. (2021) |
| Lactobacillus fermentum UCO-979C | Human gastric tissue | Inhibition of the production of proinflammatory cytokines in AGS cells has a beneficial anti-inflammatory effect | After probiotics treatment, the contents of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8 in AGS cells decreased significantly | Garcia-Castillo et al. (2018) |