Table 1.

PICO Questions for Systemic Sclerosis–associated Interstitial Lung Disease Therapies Assessed

Question	Therapy
1	Should patients with SSc-ILD be treated with cyclophosphamide?
2	Should patients with SSc-ILD be treated with mycophenolate?
3	Should patients with SSc-ILD be treated with rituximab?
4	Should patients with SSc-ILD be treated with tocilizumab?
5	Should patients with SSc-ILD be treated with nintedanib?
6	Should patients with SSc-ILD be treated with nintedanib plus mycophenolate?
7	Should patients with SSc-ILD be treated with pirfenidone?
8	Should patients with SSc-ILD be treated with pirfenidone plus mycophenolate?

Definition of abbreviation: PICO = population, intervention, comparison, outcome; SSc-ILD =  systemic sclerosis–associated interstitial lung disease.