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. 2024 Jan 10;10(1):e003901. doi: 10.1136/rmdopen-2023-003901

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Kaplan-Meier survival curves of patients using vedolizumab compared with non-vedolizumab users. (B) CT images comparison of a patient pre-vedolizumab and post-vedolizumab treatment. Red arrow indicated the perforated site. (C) Follow-up (weeks) of patients using vedolizumab in glucocorticoids tapering (mg/day, prednisolone equivalent) and haemoglobin recovery (g/L). (D) Immunohistochemical staining showed α4β7 as well as MAdCAM1 positive in the intestinal of a perforated nuclear matrix protein 2+ patient. MAdCAM1, mucosal vascular addressin cell adhesion molecule 1.