Figure 1.

Family pedigrees

Standard symbols were used. Black symbols represent individuals with cerebellar ataxia with sensory and autonomic neuropathy. Probands are indicated with black triangles. Gray symbols show family members who had gait and balance problems according to family history. Gray symbols with a central black dot represent two siblings who were evaluated within this study but were considered to have a neurodevelopmental disorder that is different from cerebellar ataxia with sensory and autonomic neuropathy, and who do not have ZFHX3 repeat expansions. The black numbers above the symbols are individual identifiers. For those family members for whom age at symptom onset was available, it is shown below the symbols in blue. Sex and gender of non-affected individuals was disguised, and sibling order partly altered to protect confidentiality. For the same reason, a few unaffected family members are not shown. UFM, unaffected family member who was analyzed genetically within this study.