Table 2.
Candidate genes for multiple NDDs
| Gene | Diseases | Omics |
|---|---|---|
| ARL17B | AD, PD | cerebellum eQTL, cortex eQTL, spinalcord eQTL |
| KAT8 | AD, PD | cerebellum eQTL, whole-brain meta-analysis mQTL, cerebellar hemisphere eQTL, cortex eQTL, tibial nerve eQTL, skeletal muscle eQTL, hypothalamus eQTL, whole-brain eQTL, cerebellum eQTL, spinalcord eQTL |
| LRRC37A2 | AD, PD | hippocampus eQTL, cortex eQTL, frontal cortex BA9 eQTL, prefrontal cortex eQTL, caudate basal ganglia eQTL, skeletal muscle eQTL, multi-ancestry, whole-brain meta-analysis eQTL, hypothalamus eQTL, liver eQTL, anterior cingulate cortex BA24 eQTL, putamen basal ganglia eQTL, amygdala eQTL, whole-brain eQTL, cerebellum eQTL, nucleus accumbens eQTL, basal ganglia eQTL, spinalcord eQTL, hippocampus eQTL, substantia nigra eQTL |
| KANSL1 | AD, PD, PSP | whole-brain meta-analysis mQTL, whole-blood mQTL, cortex eQTL, multi-ancestry whole-brain meta-analysis eQTL, spinalcord eQTL, anterior cingulate cortex BA24 eQTL |
| ARL17A | AD, PD, PSP | spinalcord eQTL, amygdala eQTL, multi-ancestry whole-brain meta-analysis eQTL, hypothalamus eQTL, hippocampus eQTL, cerebellar hemisphere eQTL, cortex eQTL, caudate basal ganglia eQTL, anterior cingulate cortex BA24 eQTL, putamen basal ganglia eQTL, cerebellum eQTL, nucleus accumbens basal ganglia |
| PRSS36 | AD, PD | whole-brain meta-analysis mQTL, cortex eQTL, cerebellar hemisphere eQTL, multi-ancestry whole-brain meta-analysis eQTL, whole-brain eQTL |
| MAPT | AD, PD, PSP | whole-brain meta-analysis mQTL, whole-blood mQTL |
| IDUA∗ | LBD, PD | whole-brain meta-analysis mQTL, whole-blood mQTL, whole-blood eQTL(eQTLgen) |
| TMEM175∗ | LBD, PD | whole-blood mQTL |
| ARHGAP27 | AD, PD, PSP | whole-blood mQTL, whole-blood eQTL (eQTLgen), multi-ancestry whole-brain meta-analysis eQTL, caudate basal ganglia eQTL, nucleus accumbens basal ganglia |
| CRHR1 | AD, PD, PSP | whole-brain meta-analysis mQTL, whole-blood mQTL, cortex eQTL, skeletal muscle eQTL |
| FMNL1 | AD, PSP | multi-ancestry whole-brain meta-analysis eQTL, whole-blood mQTL |
| PLEKHM1 | PD, PSP | cortex eQTL, frontal cortex BA9 eQTL, prefrontal cortex eQTL, caudate basal ganglia eQTL, skeletal muscle eQTL, anterior cingulate cortex BA24 eQTL, putamen basal ganglia eQTL, whole-brain eQTL |
| WNT3 | AD, PD | cortex eQTL metaBrain, skeletal muscle eQTL, tibial nerve eQTL |
| SPPL2C | AD, PD | cerebellum eQTL, prefrontal cortex eQTL |
This table shows genes with functional inferences passing multiple test corrections for multiple neurodegenerative diseases. We provide details for all the omics and diseases in which a given gene has significant associations. Asterisks indicate colocalized genes.