TABLE 2.

Education-, age-, and sex-adjusted cognitive composite domain profiles of the cognitively normal, early-onset Alzheimer's disease, and early-onset non-Alzheimer's disease groups, and group differences after controlling for global cognitive severity.

	CN	EOAD	EOnonAD	CN versus EOAD β (SE), p value	CN versus EOnonAD β (SE), p value	EOnonAD versus EOAD β (SE), p value
N	89	212	70
Episodic memory	−0.12 (0.8)	−2.38 (1.0)	−1.07(1.3)	−1.72 (0.1), p < 0.001	−0.47 (0.1), p = 0.003	−0.88 (0.1), p < 0.001
Language	−0.08 (0.7)	−1.37(1.9)	−0.80(1.1)	0.06 (0.7), p = 0.93	0.05 (0.8), p = 0.95	0.26(0.7), p = 0.70
Speed/Attention	−0.01 (1.2)	−1.93 (3.9)	−0.70(1.5)	−0.44 (0.3), p = 0.19	−0.31(0.2), p = 0.27	−0.69 (0.3), p = 0.02
Visuospatial	−0.02 (1.0)	−1.42 (4.5)	−0.75 (1.9)	−0.10 (0.5), p = 0.93	−0.46 (0.4), p = 0.27	−0.60 (0.5), p = 0.29
Executive	−0.07 (1.0)	−1.43 (2.1)	−0.59(1.4)	−0.85 (03), p = 0.005	−0.29(0.2), p = 0.27	−0.64 (0.3), p = 0.02

Note: Values represent mean and SD across cognitive domains of robust-standardized cognitive variables. EOAD versus CN, EOnonAD versus CN, an versus EOnonAD represent the beta coefficient (β, standard error (SE), and p values from the analyses comparing the respective groups after contre education, age, sex, and Mini-Mental State Examination performance.

Abbreviations: CN = cognitively normal, EOAD = early-onset Alzheimer's disease, EOnonAD = early-onset non-Alzheimer's disease; MMSE, Mini State Examination.