TABLE 5.
Consent for lumbar puncture in the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) sample.
| No | Yes | p value | Effect Size | |
|---|---|---|---|---|
| N | 150 (40.4%) | 221 (59.6%) | ||
| Age, years | 57.94 (5.0) | 58.03 (5.0) | 0.86 | 0.02 |
| Education, years | 15.75 (2.5) | 15.69 (2.4) | 0.83 | 0.02 |
| Gender, % female | 57.3% | 47.1% | 0.05 | 0.10 |
| Race (n of Yes/No within racial/ethnicgroup), % | 0.59 | 0.09 | ||
| Non-Hispanic White | 126 (40.4%) | 185 (59.6%) | ||
| Hispanic | 6 (37.5%) | 10 (62.5%) | ||
| Black/African American | 11 (45.8%) | 13(54.2%) | ||
| Asian | 5 (50.0%) | 4 (50.0%) | ||
| More than one race | 3 (33.3%) | 6 (66.7%) | ||
| Diagnostic group (n of Yes/No within diagnostic group), % | 0.39 | 0.07 | ||
| CN | 41 (46.1%) | 48 (53.9%) | ||
| EOnonAD | 25 (35.7%) | 45 (64.3%) | ||
| EOAD | 84 (39.6%) | 128 (60.4%) | ||
| Mini-Mental State Examination | 24.31 (5.7) | 24.39 (4.9) | 0.88 | 0.02 |
Note: Values for age, education, and Mini-Mental State Examination represent the mean and inter-quartile range. Gender reflects the percent of participants within either the Yes or No group that were female. Race reflects the number and percent of participants within a particular racial/ethnic category that did or did not provide consent for lumbar puncture. Diagnostic Group reflects the number and percent of participants within a specific diagnostic group that did or did not provide consent for lumbar puncture. p values reflect results of t-tests (for continuous variables) and chi-square analyses (for categorical variables) comparing Yes and No groups. Effect sizes were calculated using Cohen's d for continuous variables and Cohen's wfor categorical variables.
Abbreviations: CN, cognitively normal; No, did not provide consent for lumbar puncture; Yes, provided consent for lumbar puncture; EOnonAD, early-onset non-Alzheimer's disease; EOAD, early-onset Alzheimer's disease; LEADS, Longitudinal Early-Onset Alzheimer's Disease Study; MMSE, Mini-Mental State Examination.