Table 3.
Clinical characteristics of primary care COVID-19 cases in CPRD Aurum, by high-risk definitions
| All (n=2 257 907) | Meeting NHS highest risk conditions (n=249 972) | Meeting PANORAMIC criteria (n=6 91 593) | Meeting UKHSA clinical risk (n=225 051) | |
| Primary care cases meeting definition | -- | 11% | 31% | 10% |
| Smoking status | ||||
| Current smoker | 298 735 (13%) | 44 365 (17%) | 121 019 (18%) | 46 436 (21%) |
| Former smoker | 285 722 (13%) | 67 637 (26%) | 168 343 (24%) | 63 124 (28%) |
| Never smoked | 580 239 (26%) | 87 217 (34%) | 228 579 (33%) | 77 157 (34%) |
| Unknown | 1 093 211 (48%) | 60 753 (23%) | 173 652 (25%) | 38 334 (17%) |
| Body mass index (kg/m2) | ||||
| Mean (SD) | 27.6 (7.1) | 29.1 (6.9) | 29.5 (6.7) | 29.5 (7.5) |
| Underweight (< 18.5) | 45 194 (2%) | 3720 (1%) | 5305 (1%) | 5926 (3%) |
| Not overweight (18.5–24.9) | 226 272 (10%) | 35 766 (14%) | 81 363 (12%) | 36 716 (16%) |
| Overweight (25.0–29.9) | 204 360 (9%) | 45 261 (17%) | 113 863 (16%) | 43 758 (19%) |
| Obese (≥30.0) | 219 253 (10%) | 53 814 (21%) | 138 035 (20%) | 62 494 (28%) |
| Unknown | 1 562 828 (69%) | 121 411 (47%) | 353 027 (51%) | 76 157 (34%) |
| Charlson comorbidity index | ||||
| Mean (SD) | 0.2 (0.6) | 0.7 (1.3) | 0.5 (1.0) | 1.0 (1.3) |
| 0 | 2 003 257 (89%) | 165 823 (64%) | 487 550 (71%) | 102 790 (46%) |
| 1 or 2 | 221 370 (10%) | 74 805 (29%) | 174 287 (25%) | 99 830 (44%) |
| 3 or 4 | 24 554 (1%) | 12 659 (5%) | 21 574 (3%) | 15 961 (7%) |
| 5+ | 8726 (<1%) | 6685 (3%) | 8182 (1%) | 6470 (3%) |
CPRD, Clinical Practice Research Datalink; NHS, National Health Service; PANORAMIC, Platform Adaptive trial of NOvel antiviRals for eArly treatMent of COVID-19 In the Community; UKHSA, UK Health Security Agency.