Table 2.
Distribution of baseline characteristics according to clear cell histology subtype for GOG-210 patients, regardless of enrollment period. “Unadjusted” P-values are nominal. “Adjusted” P-values reflect a Bonferroni correction.
| Characteristic | CC |
CC-EM-M |
CC-EM-I |
CC-SER-M |
CC-SER-I |
Total |
P-value |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | N | % | N | % | Unadjusted | Adjusted | |
| Age (years) | 0.0012 | 0.0276 | ||||||||||||
| Mean | 68 | 64 | 63 | 70 | 65 | 66 | ||||||||
| St. Dev. | 10 | 11 | 9 | 9 | 10 | 10 | ||||||||
| Median | 67 | 63 | 61 | 71 | 66 | 66 | ||||||||
| Range | 41–89 | 34–90 | 46–82 | 51–91 | 45–87 | 34–91 | ||||||||
| Age < 40 | 0 | 0.0 | 1 | 1.4 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 0.3 | ||
| 40 ≤ Age < 50 | 6 | 4.4 | 6 | 8.6 | 1 | 3.1 | 0 | 0.0 | 1 | 4.8 | 14 | 4.5 | ||
| 50 ≤ Age < 60 | 25 | 18.4 | 18 | 25.7 | 13 | 40.6 | 9 | 17.3 | 5 | 23.8 | 70 | 22.5 | ||
| 60 ≤ Age < 70 | 53 | 39.0 | 27 | 38.6 | 12 | 37.5 | 15 | 28.8 | 11 | 52.4 | 118 | 37.9 | ||
| 70 ≤ Age < 80 | 38 | 27.9 | 13 | 18.6 | 4 | 12.5 | 22 | 42.3 | 3 | 14.3 | 80 | 25.7 | ||
| Age ≥ 80 | 14 | 10.3 | 5 | 7.1 | 2 | 6.3 | 6 | 11.5 | 1 | 4.8 | 28 | 9.0 | ||
|
| ||||||||||||||
| BMI (kg/m2) | 0.5629 | 1.0000 | ||||||||||||
| Mean | 30 | 33 | 29 | 30 | 31 | 31 | ||||||||
| St. Dev. | 8 | 12 | 7 | 6 | 8 | 9 | ||||||||
| Median | 29 | 31 | 30 | 30 | 29 | 30 | ||||||||
| Range | 19–53 | 15–78 | 17–47 | 17–47 | 20–49 | 15–78 | ||||||||
| BMI < 18.5 | 0 | 0.0 | 2 | 2.9 | 2 | 6.3 | 2 | 3.8 | 0 | 0.0 | 6 | 1.9 | ||
| 18.5 ≤ BMI < 25 | 41 | 30.1 | 13 | 18.6 | 7 | 21.9 | 10 | 19.2 | 5 | 23.8 | 76 | 24.4 | ||
| 25 ≤ BMI < 30 | 35 | 25.7 | 16 | 22.9 | 9 | 28.1 | 15 | 28.8 | 7 | 33.3 | 82 | 26.4 | ||
| 30 ≤ BMI < 35 | 26 | 19.1 | 17 | 24.3 | 9 | 28.1 | 17 | 32.7 | 4 | 19.0 | 73 | 23.5 | ||
| BMI ≥ 35 | 34 | 25.0 | 22 | 31.4 | 5 | 15.6 | 8 | 15.4 | 5 | 23.8 | 74 | 23.8 | ||
|
| ||||||||||||||
| Race | 0.2929 | 1.0000 | ||||||||||||
| Asian | 3 | 2.2 | 2 | 2.9 | 0 | 0.0 | 1 | 1.9 | 0 | 0.0 | 6 | 1.9 | ||
| Black/African American | 23 | 16.9 | 9 | 12.9 | 6 | 18.8 | 9 | 17.3 | 6 | 28.6 | 53 | 17.0 | ||
| Amerindian/Alaskan | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 2 | 3.8 | 0 | 0.0 | 2 | 0.6 | ||
| White | 109 | 80.1 | 58 | 82.9 | 26 | 81.3 | 40 | 76.9 | 15 | 71.4 | 248 | 79.7 | ||
| NA/NR | 1 | 0.7 | 1 | 1.4 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 2 | 0.6 | ||
|
| ||||||||||||||
| Ethnicity | 0.1380 | 1.0000 | ||||||||||||
| Hispanic | 7 | 5.1 | 0 | 0.0 | 0 | 0.0 | 2 | 3.8 | 2 | 9.5 | 11 | 3.5 | ||
| Non-Hispanic | 113 | 83.1 | 61 | 87.1 | 29 | 90.6 | 43 | 82.7 | 18 | 85.7 | 264 | 84.9 | ||
| NA/NR | 16 | 11.8 | 9 | 12.9 | 3 | 9.4 | 7 | 13.5 | 1 | 4.8 | 36 | 11.6 | ||
|
| ||||||||||||||
| Myoinvasion | 0.0818 | 1.0000 | ||||||||||||
| None | 47 | 34.6 | 11 | 15.7 | 7 | 21.9 | 15 | 28.8 | 6 | 28.6 | 86 | 27.7 | ||
| Inner Half | 50 | 36.8 | 26 | 37.1 | 17 | 53.1 | 19 | 36.5 | 6 | 28.6 | 118 | 37.9 | ||
| Outer Half | 31 | 22.8 | 30 | 42.9 | 5 | 15.6 | 14 | 26.9 | 7 | 33.3 | 87 | 28.0 | ||
| Serosa | 3 | 2.2 | 2 | 2.9 | 2 | 6.3 | 1 | 1.9 | 1 | 4.8 | 9 | 2.9 | ||
| NA/NR | 5 | 3.7 | 1 | 1.4 | 1 | 3.1 | 3 | 5.8 | 1 | 4.8 | 11 | 3.5 | ||
|
| ||||||||||||||
| Lymphovascular invasion | 0.0211 | 0.4220 | ||||||||||||
| No | 93 | 68.4 | 36 | 51.4 | 24 | 75.0 | 31 | 59.6 | 15 | 71.4 | 199 | 64.0 | ||
| Yes | 37 | 27.2 | 34 | 48.6 | 7 | 21.9 | 20 | 38.5 | 5 | 23.8 | 103 | 33.1 | ||
| NA/NR | 6 | 4.4 | 0 | 0.0 | 1 | 3.1 | 1 | 1.9 | 1 | 4.8 | 9 | 2.9 | ||
|
| ||||||||||||||
| Cervical invasion | 0.2563 | 1.0000 | ||||||||||||
| No | 98 | 72.1 | 46 | 65.7 | 20 | 62.5 | 31 | 59.6 | 14 | 66.7 | 209 | 67.2 | ||
| Glandular (G) | 4 | 2.9 | 1 | 1.4 | 2 | 6.3 | 6 | 11.5 | 1 | 4.8 | 14 | 4.5 | ||
| Stromal (S) | 8 | 5.9 | 2 | 2.9 | 1 | 3.1 | 5 | 9.6 | 0 | 0.0 | 16 | 5.1 | ||
| Both G and S | 22 | 16.2 | 19 | 27.1 | 7 | 21.9 | 8 | 15.4 | 5 | 23.8 | 61 | 19.6 | ||
| Indeterminate | 1 | 0.7 | 2 | 2.9 | 1 | 3.1 | 1 | 1.9 | 0 | 0.0 | 5 | 1.6 | ||
| NA/NR | 3 | 2.2 | 0 | 0.0 | 1 | 3.1 | 1 | 1.9 | 1 | 4.8 | 6 | 1.9 | ||
|
| ||||||||||||||
| Adnexal involvement | 0.3243 | 1.0000 | ||||||||||||
| No | 119 | 87.5 | 59 | 84.3 | 29 | 90.6 | 42 | 80.8 | 16 | 76.2 | 265 | 85.2 | ||
| Yes | 15 | 11.0 | 10 | 14.3 | 2 | 6.3 | 9 | 17.3 | 5 | 23.8 | 41 | 13.2 | ||
| NA/NR | 2 | 1.5 | 1 | 1.4 | 1 | 3.1 | 1 | 1.9 | 0 | 0.0 | 5 | 1.6 | ||
|
| ||||||||||||||
| Nodal involvement | 0.0365 | 0.6935 | ||||||||||||
| No | 107 | 78.7 | 47 | 67.1 | 26 | 81.3 | 36 | 69.2 | 13 | 61.9 | 229 | 73.6 | ||
| Yes | 21 | 15.4 | 20 | 28.6 | 3 | 9.4 | 14 | 26.9 | 7 | 33.3 | 65 | 20.9 | ||
| NA/NR | 8 | 5.9 | 3 | 4.3 | 3 | 9.4 | 2 | 3.8 | 1 | 4.8 | 17 | 5.5 | ||
|
| ||||||||||||||
| Peritoneal involvement | 0.1145 | 1.0000 | ||||||||||||
| No | 71 | 52.2 | 37 | 52.9 | 17 | 53.1 | 18 | 34.6 | 9 | 42.9 | 152 | 48.9 | ||
| Yes | 9 | 6.6 | 7 | 10.0 | 1 | 3.1 | 8 | 15.4 | 2 | 9.5 | 27 | 8.7 | ||
| NA/NR | 56 | 41.2 | 26 | 37.1 | 14 | 43.8 | 26 | 50.0 | 10 | 47.6 | 132 | 42.4 | ||
|
| ||||||||||||||
| Omental involvement | 0.3778 | 1.0000 | ||||||||||||
| No | 94 | 69.1 | 51 | 72.9 | 25 | 78.1 | 33 | 63.5 | 16 | 76.2 | 219 | 70.4 | ||
| Yes | 9 | 6.6 | 5 | 7.1 | 0 | 0.0 | 5 | 9.6 | 3 | 14.3 | 22 | 7.1 | ||
| NA/NR | 33 | 24.3 | 14 | 20.0 | 7 | 21.9 | 14 | 26.9 | 2 | 9.5 | 70 | 22.5 | ||
|
| ||||||||||||||
| FIGO stage | 0.5436 | 1.0000 | ||||||||||||
| I | 78 | 57.4 | 32 | 45.7 | 18 | 56.3 | 24 | 46.2 | 10 | 47.6 | 162 | 52.1 | ||
| II | 19 | 14.0 | 9 | 12.9 | 6 | 18.8 | 6 | 11.5 | 2 | 9.5 | 42 | 13.5 | ||
| III | 30 | 22.1 | 24 | 34.3 | 8 | 25.0 | 16 | 30.8 | 6 | 28.6 | 84 | 27.0 | ||
| IV | 9 | 6.6 | 5 | 7.1 | 0 | 0.0 | 6 | 11.5 | 3 | 14.3 | 23 | 7.4 | ||
|
| ||||||||||||||
| Planned adjuvant therapy | 0.4062 | 1.0000 | ||||||||||||
| CT/RT/CT+RT/Other | 90 | 66.2 | 53 | 75.7 | 20 | 62.5 | 39 | 75.0 | 17 | 81.0 | 219 | 70.4 | ||
| None/NA/NR | 46 | 33.8 | 17 | 24.3 | 12 | 37.5 | 13 | 25.0 | 4 | 19.0 | 92 | 29.6 | ||
BMI, body mass index; CT, chemotherapy; FIGO, International Federation of Gynecology and Obstetrics; NA/NR, not available/not reported; RT, radiotherapy