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. Author manuscript; available in PMC: 2024 Mar 21.
Published in final edited form as: Circulation. 2023 Feb 20;147(12):942–955. doi: 10.1161/CIRCULATIONAHA.122.061451

Figure 2: Heatmap of Select Phenome-Wide Association Results in White Individuals from the UK Biobank and Replication Million Veteran Program Cohorts.

Figure 2:

Heatmap of phenome-wide association results for both binary clinical traits and quantitative biomarkers. Binary clinical trait Phenome-Wide Association Study (PheWAS) was performed using the Denny PheWAS method and represents inverse-variance weighted meta-analysis of results from the Million Veteran Program and UK Biobank. Quantitative traits were rank-normal transformed prior to association analysis in the UK Biobank. The heatmap is scaled using Z-scores for all analyses and organized using hierarchical clustering via the Ward method.