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. 2024 Jan 10;12(1):e003706. doi: 10.1136/bmjdrc-2023-003706

Table 2.

Association of the total, first- and second-phase area under the curve (AUC) GLP-1/PG, AUC GLP-1/Ins, and Ins/PG ratios with post-GDM status after adjustment for age and BMI

OR 95% CI P value
GLP-1/PG
 AUC total GLP/PG 0.940 (0.895 to 0.981) 0.0078
 AUC 0–30 GLP/PG 0.850 (0.635 to 1.138) 0.2702
 AUC 30–120 GLP/PG 0.928 (0.877 to 0.974) 0.0052
GLP-1/Ins
 AUC total GLP/insulin 0.984 (0.971 to 0.997) 0.0155
 AUC 0–30 GLP/insulin 0.999 (0.635 to 1.138) 0.2702
 AUC 30–120 GLP/insulin 0.972 (0.953 to 0.989) 0.0025
Ins/PG
 AUC total insulin/PG 1.012 (0.996 to 1.031) 0.1727
 AUC 0–30 insulin/PG 0.995 (0.899 to 1.108) 0.9194
 AUC 30–120 insulin/PG 1.015 (0.997 to 1.037) 0.1392

OR and 95% CI for post-GDM were calculated based on multivariate logistic regression models adjusted for age and BMI (n=196).

AUC, area under the curve; BMI, body mass index; GDM, gestational diabetes mellitus; GLP-1, glucagon-like peptide-1; Ins, plasma insulin; OGTT, oral glucose tolerance test; PG, plasma glucose.