Table 2.
Randomized controlled trials assessing the anoscopic injection of sclerotherapy
| First author, reference | Type of treatments | |
|---|---|---|
| Index | Control | |
| Ambrose [20] | 5% phenol | Photocoagulation |
| Khoury [21] | 5% phenol (one session) | 5% phenol (multiple sessions) |
| Gartell [22] | 5% phenol | RBL |
| Senapati [23] | 5% phenol | Bulking laxative |
| Varma [24] | 5% phenol | Electrocoagulation |
| Jaspersen [25] | 5% phenol | 5% phenol under Doppler guidance |
| Kanellos [26] | 5% phenol | RBL or sclerobanding |
| Khan [27] | 5% phenol | Electrocoagulation |
| Yuksel [28] | 3% polidocanol liquid | Venotonic flavonoid |
| Moser [14] | 3% polidocanol foam | Polidocanol liquid |
| Shah [30] | 3% polidocanol liquid | Alkaline of Achyranthes aspera Linn. |
| Shafi [32] | 3% polidocanol liquid | 5% phenol almond oil |
| Neves [33] | 3% polidocanol foam | HAL-RAR under local anesthesia |
| Salgueiro [3] | 3% polidocanol foam | RBL |
RBL rubber band ligation, HAL-RAR hemorrhoidal artery ligation and recto anal repair
3 RCTs were not included in the quantitative meta-analysis because of different patient populations (patients with coexistent liver cirrhosis [29] or injection of an uncommon product [31]) or unconventional patients’ position (lithotomy rather than left lateral) [34]