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. 2024 Jan 23;12:16. doi: 10.1186/s40478-024-01733-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of progesterone receptor immunoreactive cells in the PVN and INF. A and B Absent co-localization of PR in astrocytes (GFAP) or microglia (iba1). C and D Co-localization of PR in neural progenitors (GFAP-δ and nestin). E a PVN in the human hypothalamus. b-h Absent expression of PR in CRH⁺, TRH⁺, OXT⁺, AVP⁺, SOM⁺, TH⁺ or DYN⁺ neurons in the PVN. i Co-localization of PR in KISS1⁺ neurons in the PVN. F a INF in the human hypothalamus. b-f PR expression in POMC⁺, NPY⁺, SOM⁺, KISS1⁺ and DYN⁺ neurons in the INF. g Absent co-localization of PR in CRH⁺ neurons in the INF. Scale bars: A and D, 50 μm; B and C, 20 μm; E, a-e 30 μm, f and g 15 μm; F, a and b 20 μm, c-e 30 μm. Abbreviations: AVP, arginine-vasopressin; CRH, corticotropin-releasing hormone; DYN, dynorphin; GFAP, glial fibrillary acidic protein; GFAP-δ, glial fibrillary acidic protein-delta; Iba1, ionized calcium binding adaptor molecule 1; KISS1, kisspeptin; NPY, neuropeptide Y; OXT, oxytocin; POMC, pro-opiomelanocortin; SOM, somatostatin; TH, tyrosine hydroxylase; TRH, thyrotropin-releasing hormone (for other abbreviations see legend Fig. 1)