Fig. 4.

SC-β cells have high expression and activity of transcription factors associated with progenitor states, see also Fig. S5, Fig. S6, & Table S5. a Volcano plot indicating all expressed transcription factors between SC-β and adult-β cells (Adjusted p-value <0.05). b Volcano plot indicating all expressed transcription factors between fetal-β and adult-β cells (Adjusted p-value <0.05). c Bar plots indicating percent of cells expressing known islet developmental transcription factors in SC-β, TXP SC-β, adult-β, and fetal-β cells. d Chart indicating most highly enriched regulons in SC-β, adult-β, and fetal-β cells. e Heatmap indicating scaled regulon activity of transcription factors expressed in SC-β, adult-β, and fetal-β cells. f UMAP of SC-β, adult-β, and fetal-β clustered by regulon activity. g Feature plots indicating expression and activity of β-progenitor transcription factors