Table 2.
Areas under the receiver operating characteristic curve for contralateral breast cancer risk models
| Model | AUC (95% CI) | AUC improvement (95% CI) | P |
|---|---|---|---|
| WECARE I + II | |||
| Risk factorsa | 60.7 (58.5–63.0) | Ref | Ref |
| PRS + Risk factors | 62.4 (60.2–64.7) | 1.7 (0.4–3.0) | 0.01 |
| WECARE Ib | |||
| Risk factors | 63.0 (60.0–66.1) | Ref | Ref |
| Risk factors + BRCA1/2 mutations | 65.5 (62.5–68.6) | 2.5 (0.1–4.2) | 0.003 |
| PRS + Risk factors | 65.1 (62.0–68.1) | 2.0 (0.3–3.8) | 0.03 |
| PRS + Risk factors + BRCA1/2 mutationsc | 67.7 (64.7–70.7) | 4.7 (2.4–7.0) | < 0.0001 |
AUC, area under the curve; CI, confidence interval; PRS, polygenic risk score
aRisk factors included age at first breast cancer diagnosis, age at menarche, age at menopause, number of full-term pregnancies, stage of first breast cancer, histology of first breast cancer, family history of breast cancer, chemotherapy, and hormone therapy
bInformation about BRCA1/2 deleterious mutations was only available in the WECARE I Study
cWhen comparing PRS + Risk factors + BRCA1/2 mutations to PRS + Risk factors model, the AUC improvement and P are: 2.2 (95% CI 0.5–3.8); 0.01