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. 2024 Jan 24;43:31. doi: 10.1186/s13046-024-02956-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — DSC1 expression in colon cancer samples. A Representative images of negative, moderate and intense DSC1 staining in colon cancer tissue samples subjected to immunohistochemistry. B Quantification of DSC1 staining in the analyzed tumor samples. C Representative images of DSC1 and CDH17 staining in serial tissue sections of colon cancer samples. D Representative images of the tumor invasive front showing the expression of DSC1 in budding cells (black arrows). E Representative images of DSC1 nuclear staining. Cells labeled with A and B showed positive and negative nuclear staining of tumor cells, respectively, whereas the C region indicates negative nuclear staining in fibroblasts