Table 3.
Otorhinolaryngologic adverse effects of COVID-19 vaccination by manufacturer.
| Adverse effects | At least one dose | Updated Bivalent booster | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PFIZER.BIONTECH | MODERNA | JANSSEN | P value | PFIZER.BIONTECH | MODERNA | P value | ||||||
| n(%) | IR | n(%) | IR | n(%) | IR | n(%) | IR | n(%) | IR | |||
| Hearing loss | 3,391(4.62) | 2.222 | 2,455(4.23) | 2.543 | 464(3.43) | 5.871 | <0.001 | 113(4.76) | 0.319 | 85(4.96) | 0.423 | 0.047 |
| Tinnitus (Ringing in the ears) | 9,308(12.69) | 6.100 | 7,049(12.14) | 7.303 | 1,516(11.2) | 19.182 | <0.001 | 226(9.52) | 0.637 | 168(9.8) | 0.837 | 0.007 |
| Ear infections (Otitis Media) | 453(0.62) | 0.297 | 345(0.59) | 0.357 | 56(0.41) | 0.709 | <0.001 | 51(2.15) | 0.144 | 37(2.16) | 0.184 | 0.248 |
| Meniere’s disease | 61(0.08) | 0.040 | 50(0.09) | 0.052 | 7(0.05) | 0.089 | 1.000 | 2(0.08) | 0.006 | 1(0.06) | 0.005 | 0.920 |
| Vestibular neuronitis | 89(0.12) | 0.058 | 66(0.11) | 0.068 | 5(0.04) | 0.063 | 0.619 | 6(0.25) | 0.017 | 5(0.29) | 0.025 | 0.520 |
| Dizziness or vertigo | 46,290(63.09) | 30.336 | 36,646(63.14) | 37.964 | 9,579(70.79) | 121.202 | <0.001 | 961(40.5) | 2.709 | 668(38.95) | 3.328 | <0.001 |
| Sinusitis | 1,029(1.4) | 0.674 | 941(1.62) | 0.975 | 165(1.22) | 2.088 | <0.001 | 154(6.49) | 0.434 | 117(6.82) | 0.583 | 0.016 |
| Rhinitis (Allergic and Non-allergic) | 91(0.12) | 0.060 | 83(0.14) | 0.086 | 9(0.07) | 0.114 | 0.020 | 4(0.17) | 0.011 | 4(0.23) | 0.020 | 0.414 |
| Epistaxis | 1,495(2.04) | 0.980 | 1,072(1.85) | 1.111 | 336(2.48) | 4.251 | <0.001 | 25(1.05) | 0.070 | 20(1.17) | 0.100 | 0.246 |
| Anosmia | 2,919(3.98) | 1.913 | 2,032(3.5) | 2.105 | 416(3.07) | 5.264 | <0.001 | 128(5.39) | 0.361 | 101(5.89) | 0.503 | 0.012 |
| Nasal polyps | 8(0.01) | 0.005 | 6(0.01) | 0.006 | 3(0.02) | 0.038 | 0.002 | 1(0.04) | 0.003 | 1(0.06) | 0.005 | 0.683 |
| Snoring or difficulty breathing through the nose and sleep apnea | 568(0.77) | 0.372 | 357(0.62) | 0.370 | 58(0.43) | 0.734 | <0.001 | 121(5.1) | 0.341 | 31(1.81) | 0.154 | <0.001 |
| Allergies | 4,134(5.63) | 2.709 | 3,918(6.75) | 4.059 | 439(3.24) | 5.555 | <0.001 | 126(5.31) | 0.355 | 91(5.31) | 0.453 | 0.075 |
| Tonsillitis | 50(0.07) | 0.033 | 36(0.06) | 0.037 | 8(0.06) | 0.101 | 0.008 | 3(0.13) | 0.008 | 1(0.06) | 0.005 | 0.643 |
| Laryngitis | 135(0.18) | 0.088 | 109(0.19) | 0.113 | 15(0.11) | 0.190 | 0.007 | 31(1.31) | 0.087 | 24(1.4) | 0.120 | 0.247 |
| Vocal cord polyps and nodules | 29(0.04) | 0.019 | 13(0.02) | 0.013 | 3(0.02) | 0.038 | 0.225 | (0) | 0.000 | (0) | 0.000 | |
| Laryngopharyngeal Reflux (Acid Reflux) | 235(0.32) | 0.154 | 193(0.33) | 0.200 | 22(0.16) | 0.278 | 0.002 | 13(0.55) | 0.037 | 8(0.47) | 0.040 | 0.852 |
| Epiglottitis | 6(0.01) | 0.004 | 7(0.01) | 0.007 | 2(0.01) | 0.025 | 0.041 | (0) | 0.000 | (0) | 0.000 | |
| Pharyngitis | 3,076(4.19) | 2.016 | 2,663(4.59) | 2.759 | 429(3.17) | 5.428 | <0.001 | 408(17.19) | 1.150 | 353(20.58) | 1.759 | <0.001 |
| Any IR | 73,367 | 48.081 | 58,041 | 60.129 | 13,532 | 171.218 | <0.001 | 2,373 | 6.689 | 1,715 | 8.544 | <0.001 |
| Sample size | 152,590,827 | 96,527,417 | 7,903,364 | 35,476,628 | 20,072,000 | |||||||
The data was collected from the VAERS and the CDC Covid-19 vaccinations data tracker as of August 30, 2023. The Incidence Rate(IR) per 100,000 was measured based on subjects with complete primary series vaccination and updated bivalent booster of COVID-19 vaccinations in the US. The sample size was from the CDC Data Tracker. P value by Chi-square test. The CDC did not provide the number of the complete primary series, thus it was substituted with “At Least One Dose.” The CDC did not provide the number of updated bivalent booster produced by Jassen because it was not used as one in the US.