Tests	Sensitivity (95% CI)					Specificity (CI)*
	1 to 7 d†	8 to 14 d†	15 to 21 d†	22 to 35 d†	> 35 d†
IgG	30% (22 to 39)	67% (58 to 74)	88% (84 to 74)	80% (72 to 86)	87% (80 to 92)	99% (98 to 100)
IgM	23% (15 to 34)	58% (46 to 70)	75% (64 to 84)	68% (55 to 79)	54% (38 to 69)	99% (98 to 99)
IgG/IgM‡	30% (21 to 41)	72% (64 to 80)	91% (87 to 94)	96% (91 to 98)	78% (66 to 86)	99% (97 to 99)
Total antibodies	25% (10 to 50)	84% (64 to 94)	98% (90 to 100)	70% (35 to 91)	79% (50 to 93)	99% (98 to 100)

CI defined in Glossary.

^*Meta-analysis of 35 studies (8526 cases) across all time points.

^†Days after symptom onset.

^‡Positive if either IgG or IgM is positive.