Table 3:
Rates of mortality while in hospital and at 30, 60, and 90-days by etiology of acute kidney injury
| In Hospital | 30-Day | 60-Day | 90-Day | Sub-Hazard Ratio (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Type of AKI | ||||||
| Prerenal AKI | 6.1% | 10.9% | 18.6% | 22.2% | Reference | --- |
| Hepatorenal syndrome | 24.5% | 36.1% | 45.4% | 49.0% | 2.78 2.18–3.54) | <0.001 |
| Acute tubular necrosis | 37.6% | 40.9% | 48.4% | 52.7% | 2.83 (2.36–3.41) | <0.001 |
| Other | 6.5% | 10.6% | 20.3% | 23.6% | 1.04 (0.71–1.51) | 0.85 |
| Unable to classify | 26.2% | 33.6% | 39.6% | 45.0% | 2.33 (1.75–3.09) | <0.001 |
| AKI Stage | ||||||
| Stage I | 5.1% | 11.0% | 17.9% | 21.7% | Reference | --- |
| Stage II | 11.3% | 18.9% | 28.0% | 31.6% | 1.36 (1.08–1.71) | 0.008 |
| Stage III without renal replacement therapy | 22.6% | 32.3% | 39.3% | 43.7% | 1.71 (1.38–2.13) | <0.001 |
| Stage III with renal replacement therapy | 51.1% | 46.5% | 55.6% | 59.6% | 3.63 (2.86–4.61) | <0.001 |
| AKI Response | ||||||
| Complete response | 2.2% | 5.7% | 13.1% | 17.3% | Reference | --- |
| Partial response | 11.3% | 19.3% | 29.3% | 34.3% | 2.04 (1.59–2.61) | <0.001 |
| No response | 38.5% | 44.7% | 52.3% | 55.6% | 4.85 (4.03–5.84) | <0.001 |
| Transplant Listing Status | ||||||
| Listed for liver transplant | 9.6% | 8.5% | 14.5% | 16.7% | Reference | --- |
| Not listed for liver transplant | 21.2% | 27.7% | 35.8% | 40.1% | 4.04 (3.00–5.45) | <0.001 |
Key: AKI (acute kidney injury), HRS (hepatorenal syndrome), ATN (acute tubular necrosis). Absolute rates of death at in hospital, 30, 60, and 90 days represent unadjusted mortality rates at their respective intervals. Sub-Hazard ratios and P values are derived from multivariable models using Fine and Gray analysis for 90-day mortality, adjusted for age, race, gender, transplant listing status, center, and MELD-Na score.