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Dose levels and dose-limiting toxicities
| Dose level | Adavosertib (mg/day) D1–5, 8–12 Oral |
Belinostat (mg/ m2) D1–5, 8–12 IV |
#Treated/ #DLT evaluable |
DLT event | Median # of cycles (range) |
|---|---|---|---|---|---|
| 1 | 200 | 600 | 3/3 | 2 (2–4) | |
| 2 | 200 | 800 | 3/3 | 4 (3–4) | |
| 3 | 225 | 800 | 9/3 | 1 (1–7) | |
| 4 | 225 | 1000 | 5/3 | Gr4 CRS | 2 (1–4) |
CRS cytokine release syndrome, D day of the cycle, DLT dose-limiting toxicity, Gr grade of toxicity
