TABLE 1.
Mendelian randomisation estimates for sedentary behaviour and breast cancer risk.
| Methods | Leisure television watching | Leisure computer use | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimates (OR) a | 95% CI | p‐value | p‐value for pleiotropy b or heterogeneity c | Estimates (OR) a | 95% CI | p‐value | p‐value for pleiotropy b or heterogeneity c | |
| Breast cancer | ||||||||
| Inverse‐variance weighted | 1.15 | 1.05–1.26 | 0.002 | 1 × 10−17 | 1.01 | 0.84–1.23 | 0.89 | 1 × 10−9 |
| MR‐Egger | 1.48 | 0.98–2.23 | 0.06 | 0.22 | 0.69 | 0.19–2.48 | 0.57 | 0.55 |
| Weighted median | 1.16 | 1.05–1.27 | 0.003 | 1.06 | 0.87–1.28 | 0.57 | ||
| MR‐PRESSO | 1.12 | 1.03–1.20 | 0.008 | 3 × 10−8 | 1.04 | 0.88–1.23 | 0.62 | 8 × 10−4 |
| Luminal A breast cancer | ||||||||
| Inverse‐variance weighted | 1.20 | 1.06–1.35 | 0.002 | 6 × 10−19 | 1.06 | 0.84–1.34 | 0.62 | 4 × 10−6 |
| MR‐Egger | 1.55 | 0.90–2.69 | 0.11 | 0.34 | 1.58 | 0.35–7.10 | 0.55 | 0.60 |
| Weighted median | 1.15 | 1.01–1.31 | 0.03 | 1.06 | 0.83–1.35 | 0.66 | ||
| MR‐PRESSO | 1.14 | 1.03–1.26 | 0.01 | 3 × 10−7 | 1.06 | 0.87–1.31 | 0.54 | 0.003 |
| Luminal B breast cancer | ||||||||
| Inverse‐variance weighted | 1.14 | 0.94–1.38 | 0.19 | 0.03 | 0.89 | 0.58–1.36 | 0.58 | 0.02 |
| MR‐Egger | 1.16 | 0.47–2.89 | 0.74 | 0.96 | 1.95 | 0.12–30.3 | 0.63 | 0.57 |
| Weighted median | 1.13 | 0.86–1.48 | 0.40 | 0.97 | 0.57–1.67 | 0.92 | ||
| MR‐PRESSO | 0.82 | 0.57–1.17 | 0.28 | 0.11 | ||||
| Luminal B HER2 negative breast cancer | ||||||||
| Inverse‐variance weighted | 1.14 | 0.96–1.36 | 0.13 | 0.004 | 1.03 | 0.76–1.40 | 0.84 | 0.19 |
| MR‐Egger | 1.07 | 0.48–2.39 | 0.86 | 0.88 | 0.27 | 0.04–2.25 | 0.23 | 0.22 |
| Weighted median | 1.30 | 1.03–1.63 | 0.03 | 1.15 | 0.76–1.75 | 0.52 | ||
| MR‐PRESSO | ||||||||
| HER2 enriched breast cancer | ||||||||
| Inverse‐variance weighted | 1.21 | 0.91–1.60 | 0.19 | 0.02 | 0.67 | 0.40–1.13 | 0.13 | 0.69 |
| MR‐Egger | 1.31 | 0.35–4.95 | 0.68 | 0.90 | 0.08 | 0.00–2.16 | 0.13 | 0.20 |
| Weighted median | 1.25 | 0.84–1.86 | 0.28 | 0.65 | 0.31–1.35 | 0.25 | ||
| MR‐ PRESSO | ||||||||
| Triple negative breast cancer | ||||||||
| Inverse‐variance weighted | 1.16 | 0.99–1.35 | 0.06 | 0.10 | 0.68 | 0.50–0.93 | 0.02 | 0.24 |
| MR‐Egger | 1.54 | 0.72–3.29 | 0.27 | 0.45 | 0.41 | 0.05–3.35 | 0.40 | 0.63 |
| Weighted median | 1.31 | 1.04–1.67 | 0.02 | 0.73 | 0.47–1.14 | 0.16 | ||
| MR‐PRESSO | ||||||||
Abbreviations: CI, confidence interval; MR, Mendelian randomisation; OR, odds ratio; MR‐PRESSO, MR pleiotropy residual sum and outlier test.
a
The estimates correspond to a standard deviation increase in duration of sedentary activity.
b
p‐value or pleiotropy based on MR‐Egger intercept.
c
p‐value for heterogeneity based on Q statistic.