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. 2023 Dec 22;8(24):e174293. doi: 10.1172/jci.insight.174293

Figure 7. Deletion of Mpc1 alone or both Mpc1 and Cpt1a suppresses osteoclasts in female mice only.

Figure 7

(AJ) Representative images and quantification of trabecular bone parameters by μCT in males (AE) and females (FJ) with Mpc1 single deletion in the osteoclast lineage. dCKOMpc: LysMCre/Cre Mpc1fl/fl. (K and L) Histomorphometric quantification of osteoclasts. (M and N) mRNA levels in BMMs as assayed by RT-qPCR. dCKOCptMpc: LysMCre/Cre Cpt1afl/fl Mpc1fl/fl. (OV) Quantification of trabecular bone parameters by μCT in males (OR) and females (SV) with Mpc1 and Cpt1a double deletion. (W and X) Serum CTX-I (W) and P1NP (X) levels of female mice with double deletion. (Y and Z) Histomorphometric analyses of osteoclasts. *P < 0.05, **P < 0.01, 2-tailed Student’s t test. Error bars: SD.